WebKim KS, et al. (1986) Saccharomyces cerevisiae contains two functional citrate synthase genes. Mol Cell Biol 6 (6):1936-42 PMID: 3023912. Lewin AS, et al. (1990) Citrate synthase encoded by the CIT2 gene of Saccharomyces cerevisiae is peroxisomal. Mol Cell Biol 10 (4):1399-405 PMID: 2181273. Citrate synthase is commonly used as a quantitative enzyme marker for the presence of intact mitochondria. Maximal activity of citrate synthase indicates the mitochondrial content of skeletal muscle. [6] The maximal activity can be increased by endurance training or high-intensity interval training, [6] but … See more The enzyme citrate synthase E.C. 2.3.3.1 (previously 4.1.3.7)] exists in nearly all living cells and stands as a pace-making enzyme in the first step of the citric acid cycle (or Krebs cycle). Citrate synthase is localized within See more • Citrate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an overview of all the structure information available in the … See more Citrate synthase's 437 amino acid residues are organized into two main subunits, each consisting of 20 alpha-helices. These alpha helices compose approximately 75% of citrate synthase's tertiary structure, while the remaining residues mainly … See more Mechanism Citrate synthase has three key amino acids in its active site (known as the catalytic triad) which catalyze the conversion of acetyl-CoA [H3CC(=O)−SCoA] and oxaloacetate [ O2CCH2C(=O)CO2 ] into citrate [ O2CCH2C(OH)(CO2 … See more
What type of reaction is citrate synthase? - Studybuff
WebJan 4, 2005 · PTHR11739:SF8 CITRATE SYNTHASE, MITOCHONDRIAL 1 hit; PRINTS. PR00143 CITRTSNTHASE; PROSITE. View protein in PROSITE; PS00480 … WebMar 8, 2024 · Citrate synthase (CS) catalyzes the reaction that produces citrate and CoA from oxaloacetate and acetyl-CoA in the tricarboxylic acid (TCA) cycle. All TCA cycle enzymes are localized to the mitochondria in the model organism, the red alga Cyanidioschyzon merolae. The biochemical properties of CS have been studied in some … simon miller whatculture twitter
Reversibility of citrate synthase allows autotrophic growth of a ...
WebSimilarly, citrate synthase is not allosterically regulated either, the rate is controlled by concentration of substrate and product, oxaloacetate and citrate respectively. However, isocitrate dehydrogenase is an allosterically regulated enzyme and is considered one of the rate limiting step for the TCA cycle. It show cooperative binding when ... WebOther articles where citrate synthase is discussed: metabolism: Formation of coenzyme A, carbon dioxide, and reducing equivalent: …reaction [38] is catalyzed by citrate … WebSep 8, 2024 · Citrate synthase and oxoglutarate dehydrogenase (OGDH) catalyze the condensation of acetyl-CoA from glycolysis or other dissimilatory reactions with … simon milton webber