Cyp4a11
http://www.biodragon.cn/cgkt/97386.html Cytochrome P450 4A11 is a protein that in humans is codified by the CYP4A11 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids … See more • Human CYP4A11 genome location and CYP4A11 gene details page in the UCSC Genome Browser. See more • Kawashima H, Kusunose E, Kubota I, Maekawa M, Kusunose M (Jan 1992). "Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega … See more
Cyp4a11
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WebCYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. Gao H, et al. Int J Mol Med, 2024 Apr. PMID … WebJun 12, 2009 · CYP4A11 is the only human CYP4A gene that is significantly expressed in liver and kidney, and it remains unclear whether its expression is regulated by mechanisms that govern the expression of CYP4A genes in other species.
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WebNov 27, 2006 · ab3573 labelling Cytochrome P450 4A/CYP4A11 in the cytoplasm of Rat kidney tissue (right) compared with a negative control in the absence of primary antibody (left). To expose target proteins, antigen … WebEnzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of the CYP4A11 and CYP4F2 genes are associated with the risk of CAD in Russian population.
WebCYP4A11 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 519 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Align Download Add Add a publication Entry feedback Function
eastorange-njWebNov 29, 2024 · However, the physical alignment of CYP4A11 and CYP4A22 genes exposed small insertions and deletions in the introns, with the most conserved being intron 8, while introns 3, 6, and 9 showed the highest degree of divergence, resulting in a 96% overall sequence identity between CYP4A11 and CYP4A22 genes. Furthermore, the translated … east orange new jersey zoning mapWebJan 28, 2024 · The present study aimed to investigate the role of cytochrome P450 4A11 (CYP4A11) in the pathogenesis of NAFLD. The levels of plasma CYP4A11 and lipid … culver\u0027s beaver dam wiWebFeb 11, 2000 · However, CYP4A11 appears to play a more important role in renal formation of 20-HETE than in its hepatic formation, since the anti-CYP4A11 mediated inhibition of AA ω-hydroxylase activity obtained with kidney samples was markedly greater than that observed with liver samples (12.9 ± 9%) (Fig. 5 B ). culver\u0027s beef pot roast dinner reviewWebImmunocytochemistry showed CYP4F2 and CYP4A11 expression in only the S2 and S3 segments of proximal tubules in cortex and outer medulla. Our results demonstrate that CYP4F2 and CYP4A11 underlie conversion of AA to 20-HETE, a natriuretic and vasoactive eicosanoid, in human kidney. Considering their proximal tubular localization, these P450 ... culver\u0027s bbu universityWebMar 9, 2024 · Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). east orange nj cannabisWebThe cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This … culver\u0027s beef pot roast dinner