WebWe recently showed that DHX9 is responsible for resolving long double-stranded RNA (dsRNA) that our cells naturally produce during transcription of genes that contain copious amounts of Alu insertions in their intronic regions (Aktas et al. Nature 2024). Under normal conditions, these sequences are retained in the nucleus and are not allowed to ... WebNov 13, 2024 · Taken together, we demonstrated and linked the functional role of DHX9 phosphorylation to oncogenic circCCDC66 expression during the development of …
DHX9-dependent recruitment of BRCA1 to RNA promotes DNA
WebJul 5, 2024 · Since DHX9 associates with the transcription complex we hypothesized that the increased intensity in DHX9 staining might reflect the accumulation of stalled RNA … WebSep 28, 2024 · DExD/H-box helicase 9 (DHX9), or RNA helicase A (RHA), is an abundant multifunctional nuclear protein. Although it was previously reported to act as a cytosolic DNA sensor in plasmacytoid dendritic cells (pDCs), the role and molecular mechanisms of action of DHX9 in cells that are not pDCs during DNA virus infection are not clear. how much of the moon have we explored
Cancers Free Full-Text Oxaliplatin-Induced DHX9 …
WebNov 22, 2016 · Oxaliplatin remains the reference treatment of advanced colorectal cancer and more broadly of digestive cancers, incorporated in the FOLFOX protocol (folinic acid, 5-Fu, Oxaliplatin). But oxaliplatin chemotherapy is certainly the most neurotoxic, as on average 90% of patients develop acute neuropathic disorders (within hours or days of the ... WebJun 22, 2024 · In LIHC, DHX9, DHX32, and DHX15 play important roles in promoting cancer cell motility and proliferation, inhibiting cell apoptosis, and indicating a poor prognosis (34–36). In addition, DHX9 is also involved in promoting oncogenic circular RNA CCDC66 expression and the development of chemoresistance after oxaliplatin treatment . … WebMay 19, 2024 · The DNA/RNA helicase DHX9 is emerging as an important regulator of cellular processes that are often deregulated in cancer. Methods: To investigate … how do i turn off iphone 12